Senior Research Scientist - Biology Job in O2h Technology Private Limited

Senior Research Scientist - Biology

Apply Now
Job Summary

Senior Research Scientist - Biology

Job description


  • Reporting directly to the head of biology, lead a group of in vitro assay biologists, coaching group members to improve skills and productivity

  • Independently design, conduct, optimize and proactively troubleshoot assays

  • Develop, optimize and validate biochemical and cellular assays for the hit to lead identification, lead optimization and functional characterization of small molecules

  • Work on the bench implementing state-of-the-art technologies for the different assay platforms - managing, motivating and training junior members within the group

  • Ensure robust and high quality assays with efficient use of automation and instrumentation

  • Data processing, interpretation and presentation to cross functional team members and stakeholders

  • Proposing, planning, quoting, tracking reagent needs, usage and executing time lines for each study

  • Work closely with other biology groups involved in screening, protein biology and ADME, offering integrated drug discovery support alongside chemistry for multiple client-based projects

Job requirements


  • Strong expertise in basic molecular biology, cell biology and biochemistry techniques

  • Expertise in site-directed mutagenesis, transcriptional studies, luciferase reporter assays and qRT-PCR

  • Working knowledge of CRISPR-CAS9 knock-out and/or siRNA/shRNA knock-down studies

  • Extensive cell culture experience and in handling different immortalized, primary cell lines and 3D cultures

  • Ability to perform transient transfections and generate stable cell lines

  • Good working knowledge of immunoprecipitation and Western blotting for protein analysis and quantification

  • Experience in fluorescence microscopy and high-content imagining is an added benefit

  • Experience in targeted protein degradation, target engagement assays (e.g. nanoBRET, CETSA) is an added benefit

  • Managerial experience of junior scientists

  • Excellent data analysis and interpretation skills

  • Ability to participate in project team meetings and contribute in the project(s) intellectually

  • An ability to overcome technical challenges and exercise sound judgment under pressure

  • High self-motivation to initiate projects and work independently under aggressive deadlines

  • A strong technical knowledge with exceptional attention to detail

  • An excellent personal rapport and an ability to engender trust and respect

  • An ability to work well as part of a small focussed team and build relationships

  • An exceptional communication skills and an ease in interaction with all stakeholders

  • An infectious enthusiasm for life, work and making a difference to the world in which we live

  • A bright, friendly, flexible personality with agility to switch between different skill sets

  • An exceptional organisational skills that thrives working in a fast-paced and vibrant team environment

  • Positivity, focus and a winning mentality allied with kindness

  • Curiosity, energy, creativity, and bravery with a strong desire to help to build the o2h culture

Apply for this job
Experience Required :

Fresher

Vacancy :

2 - 4 Hires

Similar Jobs for you

See more recommended jobs