Senior Research Scientist - Biology Job in O2h Technology Private Limited
Senior Research Scientist - Biology
- Ahmedabad, Gujarat
- Not Disclosed
- Full-time
- Permanent
Senior Research Scientist - Biology
Job description
Reporting directly to the head of biology, lead a group of in vitro assay biologists, coaching group members to improve skills and productivity
Independently design, conduct, optimize and proactively troubleshoot assays
Develop, optimize and validate biochemical and cellular assays for the hit to lead identification, lead optimization and functional characterization of small molecules
Work on the bench implementing state-of-the-art technologies for the different assay platforms - managing, motivating and training junior members within the group
Ensure robust and high quality assays with efficient use of automation and instrumentation
Data processing, interpretation and presentation to cross functional team members and stakeholders
Proposing, planning, quoting, tracking reagent needs, usage and executing time lines for each study
Work closely with other biology groups involved in screening, protein biology and ADME, offering integrated drug discovery support alongside chemistry for multiple client-based projects
Job requirements
Strong expertise in basic molecular biology, cell biology and biochemistry techniques
Expertise in site-directed mutagenesis, transcriptional studies, luciferase reporter assays and qRT-PCR
Working knowledge of CRISPR-CAS9 knock-out and/or siRNA/shRNA knock-down studies
Extensive cell culture experience and in handling different immortalized, primary cell lines and 3D cultures
Ability to perform transient transfections and generate stable cell lines
Good working knowledge of immunoprecipitation and Western blotting for protein analysis and quantification
Experience in fluorescence microscopy and high-content imagining is an added benefit
Experience in targeted protein degradation, target engagement assays (e.g. nanoBRET, CETSA) is an added benefit
Managerial experience of junior scientists
Excellent data analysis and interpretation skills
Ability to participate in project team meetings and contribute in the project(s) intellectually
An ability to overcome technical challenges and exercise sound judgment under pressure
High self-motivation to initiate projects and work independently under aggressive deadlines
A strong technical knowledge with exceptional attention to detail
An excellent personal rapport and an ability to engender trust and respect
An ability to work well as part of a small focussed team and build relationships
An exceptional communication skills and an ease in interaction with all stakeholders
An infectious enthusiasm for life, work and making a difference to the world in which we live
A bright, friendly, flexible personality with agility to switch between different skill sets
An exceptional organisational skills that thrives working in a fast-paced and vibrant team environment
Positivity, focus and a winning mentality allied with kindness
Curiosity, energy, creativity, and bravery with a strong desire to help to build the o2h culture
Fresher
2 - 4 Hires